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Tuesday, July 28, 2020 | History

2 edition of pharmacokinetics of antipyrine in the rabbit during fever found in the catalog.

pharmacokinetics of antipyrine in the rabbit during fever

Lun-Hing Kenneth Poon

pharmacokinetics of antipyrine in the rabbit during fever

by Lun-Hing Kenneth Poon

  • 108 Want to read
  • 39 Currently reading

Published .
Written in English


The Physical Object
Pagination1 v., 111 leaves
Number of Pages111
ID Numbers
Open LibraryOL19074979M

A year-old woman experienced fever and convulsions. Effects of administration route on valproate pharmacokinetics in the rabbit. Article. Summary— Analgesia can be obtained during. Drug fever is usually suspected when no other cause for the fever can be elucidated, sometimes after antimicrobial therapy has already been started. In nonsensitized individuals receiving a drug for the first time, the onset of fever is highly variable and differs among drug classes, but most commonly appears after 7–10 days of drug.

Abstract. 1. The neuropharmacokinetics of antipyrine, a readily dialysable drug, in rat frontal cortex were studied and the effect of sampling time and contribution of period sampling and dialysate dead volume investigated in relation to tmax, Cmax, AUC and t1/2 values. Some Insights into the Variations in Antipyrine Pharmacokinetics in the Rat. Research Communications in Chemical Pathology and Pharmacology (). Shrewsbury R.P., Oliver S.R., Anderson W.T., Lewis L.M., White L.G.: The Effect of Varying Percentages of Hemodilution with Fluosol-DA and Normal Saline of Antipyrine Metabolism in the Rat.

The effect of fever on pharmacokinetics has received only scant attention in the clinical literature. If fever Tachycardia is common during fever, and the as- Forsyth et al. [39] in studies of antipyrine metabo-lism in children. Thus, fever appears to have vari . The symptoms of rabbit fever appear in just 2 to 10 days. There are several types of rabbit fever (tularemia), such as: Ulceroglandular tularemia; This is the most common disease form. Symptoms comprise: Skin ulcer at the site of infection due to an animal or .


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Pharmacokinetics of antipyrine in the rabbit during fever by Lun-Hing Kenneth Poon Download PDF EPUB FB2

The rabbit was utilized for examining the pharmacokinetics of three compounds (acetaminophen, AC; antipyrine, AN; and salicylic acid, SA) in nursing adults and their suckling offspring and for assessing the ability of a diffusional model to predict milk to serum drug concentration ratios (M S) from in vitroAN, and SA serum concentration time profiles declined Cited by: Pharmacokinetics of antipyrine and trimethoprim in pigs with endotoxin‐induced fever Article in Journal of Veterinary Pharmacology and Therapeutics 2(3) - April with 11 Reads.

Effects of Iproniazid on Antipyrine Pharmacokinetics The effect of iproniazid phosphate 50 mg/kg IP in three rabbits is shown in Table 3. There was a significant lengthening of T^i and a corresponding reduction in PC.

Figure 1 shows the change in 7"i/2 after iproniazid in one of the by: 2. The application of a gas-liquid chromatographic (GLC) method to measurements of antipyrine in plasma for the estimation of antipyrine half-life (T 1/2) in the rabbit is described and is Cited by: 2. The influence of ectotoxin induced pyrexia on the pharmacokinetics of gentamicin in the rabbit.

Journal of Pharmacology and Experimental Therapeutics,Cited by: 9. 1 The elimination of antipyrine from saliva was measured in six children aged 5 months to 5 years during fever and during a control period 2‐4 weeks after the cessation of fever. 2 The mean (+/‐ s.d.) saliva antipyrine clearance during fever, 32 +/‐ 13 ml kg‐1 h‐1, was nearly 50% less than that when the children were afebrile, 50 +/‐ 22 ml kg‐1 h‐1 (P less than ).

Research in Veterinary Science60, Effect of age on the pharmacokinetics of antipyrine in calves K. JANUS, J. SUSZYCKA, University of Agriculture, Laboratory of Physiological Chemistry, Department of Animal Physiology, Szczecin, Poland SUMMARY Single doses of 15 mg kg-1 antipyrine were given intravenously to 10 female calves of the black and.

Differences in AP pharmacokinetics between pregnant and non-pregnant rats were significant during the distribution phase (t 1/2 = and min, respectively), whereas the elimination phase was unaffected.

AP has been demonstrated, as expected, to be an excellent marker for drug transport studies through different body barriers. Abstract. It is shown that the parameters of antipyrine pharmacokinetics during cold exposure depend on individual resistance to hypoxia. High-resistant rats are characterized by less intense metabolism and more rapid normalization of pharmacokinetic parameters than lowresistant rats characterized by shortened elimination half-time corresponding to a more rapid metabolism of xenobiotics under.

The pharmacokinetics of antipyrine have been studied in patients with schistosomiasis. In comparison to a control group of subjects (n = 6), patients with early (active) schistosomiasis (passing live ova in urine or stools without clinical and laboratory evidence of liver involvement; n = 6) exhibited similar pharmacokinetic parameters.

The plasma half-life and metabolic clearance rate of antipyrine, a drug metabolized by hepatic microsomal enzymes, were determined in 33 normal volunteers during a basal state and during fever. Therefore, the assumption of a constant value for V for both groups of rats up to the time for saliva collection is reasonable, and the effect of fever on hepatic elimination of antipyrine is consistent with reports on the effect of fever on the elimination of other compounds in the rat [22] and on the elimination of antipyrine in the rabbit [23].

Malaria infection and fever caused a decrease in the. The pharmacokinetics of antipyrine were examined after oral and intravenous administration to 20 epileptic subjects receiving antiepileptic drug therapy. Bioavailability was essentially complete (mean bioavailability % +/- (s.d.] indicating that even in enzyme induced subjects, antipyrine behaves as a restrictively eliminated compound.

The pharmacokinetics of 14 C-antipyrine were studied in rats with fever induced by intracerebroventricular injections of prostaglandin E rats were used as their own controls with at least 5 days between the control and the fever period.

The effect of temperature on rates of antipyrine metabolism (oxidation followed by conjugation) and paracetamol metabolism (conjugation) was aslo. intravenous-rabbit LDLo mg/kg "Handbook of Toxicology," 4 vols., Philadelphia, W.B.

Saunders Co., Vol. 5, Pg. 14, Transformation of phenazone-type drugs during chlorination. PubMed: Pharmacokinetics of antipyrine in calves at neonatal period fed with casein supplemented food.

To assess fever-induced changes in theophylline pharmacokinetics in the rabbit model, six healthy, male, New Zealand white rabbits were studied using a randomized, matched-pair design. In treatment 1, 15 mg/kg of theophylline was infused into the left marginal ear vein, and several blood samples were collected from the opposite ear for 10 hours.

Influence of endotoxin induced fever on the pharmacokinetics of intramuscularly administered cefepime in rabbits Ayman Goudah, 1 Samar M.

Mouneir, 1 Jae-Han Shim, 2 A. Abd El-Aty 1, 2 1 Department of Pharmacology, Faculty of. The influence of 2 weeks oral intake of nifedipine (2×20 mg) on the oxidative metabolism of antipyrine was investigated in 12 normal volunteers, who had mg antipyrine solution orally before and after the course of nifedipine.

There were no statistically significant differences in the saliva pharmacokinetic parameters of antipyrine on both occasions. Clinical Pharmacokinetics Service along with Pharmacy Practice Residents and PY4 pharmacy students as part of a resident/student rotation in Clinical Pharmacokinetics.

Patients with serum drug concentrations on non-covered services are identified on a daily. with pyrogen induced fever (Song et al., ) and antipyrine half-lives in febrile patients (Blin et al., ) has been recorded. During induced fever a higher level of quinine was observed in.

Antipyrine is a pyrazolone derivative that is 1,2-dihydropyrazolone substituted with methyl groups at C-1 and C-5 and with a phenyl group at N It has a role as a non-narcotic analgesic, an antipyretic, a non-steroidal anti-inflammatory drug, a cyclooxygenase 3 inhibitor, a .The present experiment was designed to study the pharmacokinetics of levofloxacin in six healthy cross bred female cow calves (4 to 6 months age) weighing between 40 to 80 kg.

Plasma from blood was separated by centrifugation at 10, rpm. Quantitative estimation of levofloxacin was done by UV-VIS spectrophotometer at nm. The mean maximum plasma concentration (Cpmax) of levofloxacin in.Pharmacokinetics. Toxicity. Drug Safety. is widely used as an over-the-counter fever reducer and pain reliever.

However, the current therapeutic use of APAP is not optimal. The relative.